2004 Minnesota Scholars of Distinction in Science

 

Thai Doan Grade

(no photo)

2004 Coon Rapids High School

Generally, my role in science at the high school level generally addresses science in nature. My first project dealt with the creation of soap and its comparison to commercial products in terms of biodegradability and safety in society. It was only at the Minnesota State Science & Engineering Fair that I learned that soap was basically in every chemistry book on the planet. From there, I researched the neem tree (Azadirachta indica) and how when various substances are extracted from the tree itself, the substances have been known to have miracle related effects. Finally, participating in the Research and Engineering Apprenticeship Program allowed me to investigate the use of mutually symbiotic, nitrogen-fixing bacteria on prairie legumes, using the bacteria as an alternate source of nitrogen fertilizer. I am currently adding revisions to my written paper on nitrogen deposition and will have it pending for review shortly.

 

 

 

Scott McDonald

2004 Thomas Jefferson, Bloomington

Through my research at the University of Minnesota, I have been able to design and fabricate a completely functional micro-fluidic device. Under the guidance of Professor Ziaie, I have been able to expand my though process with regard to the scientific area involved.

 

I have been able to combine aspects of mechanical engineering, chemical engineering and physics in my design and fabrication process. This being a human implantable micro fluidic pump, I have had several contacts with researchers in the biomedical field. This meld between science and human physiology had led me to approach how important such research is to the advancement of medical science and other disciplines.

 

 Prior to my undertaking this design and fabrication project, Professor Ziaie assigned volumes of reading about research methods and techniques for me to investigate. Many days were spent at the Institute of Technology Library and the University of Minnesota investigating different and various research methods. This research gave me a basic and practical understanding of many scientific research methods.

 

Based on my design and fabrication hypothesis and utilizing the knowledge gained in studying different scientific research methods, I have been able to fabrication a very productive and functional human implantable micro-fluidic pump. In fact, the design and fabrication process has led to some references to a future manufacturing of this item. I am very fortunate to have been able to work with Professor Ziaie and his graduate staff in this endeavor.

 

The design and fabrication of this pump has led to my efforts in co-authoring an international conference paper submission for E.M.B.S. conference to be held later this year. I was also chosen to present a speech about my research and research product by the mentor connection staff at the mentor connection open house. During the open house experience, I had to prepare a poster display outlining the basic principles of my research and I also had to answer any questions people had as they observed my research.

 

 

 

William Mitchell

2004 Breck School

 

I have done chemical research on a material which can be used for electrical generation, illumination, and as a material for microchips. The aspect of illumination has particularly intrigued me, and I have done some research into lighting using devices that are made from similar materials to those that I worked with. I found that these devices can greatly reduce the energy needed to provide the same amount of illumination. Further work is still needed, though, to improve this technology and decrease the energy consumption of the world.

 

 

 

 

 

 

 

 

 

Ning Zhou

2004 Wayzata Senior High School

 

Two years ago, I proposed and conducted a research project at the University of Minnesota in which I investigated embryonic development of the neuronetwork between the eye and the brain and discovered a patterned growth of neuron projections in the developing chick embryo. After comparing my research results with those of prior studies, I was genuinely surprised that I had uncovered the timing of the development of a patterned neuronal growth between the eye and the brain, which contributes new knowledge to the scientific community about embryonic development of the eye-brain connection in the nervous system. The feeling that I received from knowing that my finding would contribute to ongoing research in developing medical technologies such as gene therapy and stem cell transplantation for patients with eye diseases strengthened my determination and passion for science. Following this first great experience, last summer I spent six weeks at Harvard Medical School where I completed another project in which I investigated genetic modulation of a brain structure called the corpus callosum in mice. After completion of this project, I discovered a genetic locus on chromosome 10 and two interactive loci on chromosomes 1 and 6 in the mouse genome that significantly contributed to corpus callosum size, which is significant because the corpus callosum has been associated with several human diseases, including schizophrenia, dyslexia, and Attention Deficit Hyperactivity Disorder. Knowing that my discovery of genetic modulation of the corpus callosum will help other scientists find cures for these diseases through measures to identify responsible genes was once again very exhilarating and awe-inspiring.

 

 

 

 

 

 

2004 Minnesota Scholars of Distinction in Science

Honorable Mention

 

Sarah Blasing

2004 Edina High School

 

A substantive knowledge base in science requires not only classroom instruction, but also advanced analysis and student-initiated exploration. Here is a summary of academic pursuits and accomplishments in high school. In ninth grade I took an enriched physics and chemistry course. In tenth grade, I took enriched biology. This class had substantial instruction to enable students to take the AP biology test; I did and received a 5 indicating an "extremely well qualified" knowledge base in biology. In eleventh grade I skipped the introductory chemistry course and tested into the senior Advanced Placement Chemistry class. This was a really difficult course that was half instruction based and half laboratory based. I had the opportunity to learn more than I had ever imagined and was honored to receive on of the five ‘A’ grades given under the class grading scale. This class also thoroughly prepared its students to take the AP chemistry test; I did and again received a 5. In twelfth grade I took Enriched Physics, though it was not required, to broaden my knowledge of the sciences. As a culminating semester project, my group and I studied lightning through a mentor type relationship with several scientists at the Bakken Museum of Electricity. I plan on taking the AP physics test after this year as well. Also during my twelfth grade year, the Advanced Placement Calculus course I took frequently used physic problems as examples and I was able to integrate my mathematical knowledge with my scientific knowledge.

 

 

 

 

 

Cindy Fei

(no photo)

 

2004 Wayzata High School

 

This year I participated in a mentorship program called “Mentor Connection” and integrated my knowledge of science with the area of medicine. I mentored under a pediatrician, Dr. Teresea Reid, for six months (10 hrs/wk); practically every experience was an opportunity for me to apply my knowledge of science. In studying children’s ailments with Dr. Reid, I was able to access my biology knowledge and gain a deeper understanding of the systems of the body. I specifically was able to learn how diseases are acquired, prevented, and treated. I was also able to see the effect science has had on the prenatal and infancy care of children in hospitals during my time in the nursery at Hennepin County Medical Center. For example, one day in the nursery I got the chance to apply my study of light in Enriched Physics. Many infants are born with Jaundice, a yellow coloring of the skin caused by increased levels of circulating bilirubin in the blood. A “bili-blanket” is a blanket that emits ultraviolet light, which is able to break down the circulating bilirubin, and return infants’ bilirubin level and skin coloring to normal. I saw that day, and have continued to see, how the pursuit of science has led to the development of many scientific tools that directly impact infant care. I have also seen the impact science has on society during my time with Dr. Reid. I specifically remember one night in the Pediatric Intensive Care Unit when an African mother of an ailing two-year-old told me how thankful she was that she had moved to American. She said “Africa does not have any of the equipment and to save my daughter’s life and make her well.” In this context, I have seen the unimaginable impact that science has on individual lives everyday. One way I have actively sought to integrate my knowledge of science with other disciplines outside of my mentorship is by studying the physics applications in calculus. Most students take the AP physics test that only tests their knowledge of physics, but I have opted to take a different AP physics test that combines that knowledge with knowledge of calculus. This has proved to be a challenge but it is also very exciting!

 

 

 

Yuliya Perepelitsa

2004 Thomas Jefferson Senior High School

 

By being involved in many scientific activities, I understand the relationship among sciences, sciences and other disciplines, and science and society. By being involved in the Science Olympiad and having an understanding of multiple scientific fields, I see that they are all intertwined and all depend on one another. For example in order to understand something in biology, you would need to have an understanding of chemistry or physics. Oslo, you could look at one object, for example a human body, on so many levels. You could look at it from a point of view of chemistry, biology, or physics and you would see that they all connect and have this great relationship among themselves. I have an understanding of the relationship between science and other disciplines through my study of literature. By understanding the work done by Sigmund Froid or Darwin, it is very easy to see that disciplines like science and psychology are very interdependent. Science is not an isolated field; it applies to all kinds of disciplines and studies. Without science, architecture, farming, and many other fields, would not be as effective and practical. Science also plays a huge role in technology and in inventions. Without this other fields would seize to exist. Science also has a great impact on fields such as the economy and the government. Today, a global economy is possible because of science and the whole world is able to communicate though technology. Also, science both solves and creates problems for the government today. I also have an understanding of the relationship between science and society. A great example of this would be the way that science affects religion and the way that religion affects science. Scientific technology also has a great affect on society. Today people are trying to keep up with all of the new technology and are trying to be as efficient as they can. Some people have incredibly fast lives that are dependent on technology. Science also helps people medically, it connects people, and it provides the comforts of today society. I am able to see how science and medicine affect infants and their families at the hospital. But science also has some negative connections with society. Some people are becoming too dependent on technology, on medicine, and on other science. Some parts of society also use science in a negative way. In conclusion, science in connected to almost every aspect of life, and therefore, is very important.

 

 

 

Amy Toberman

2004 Robbinsdale Armstrong High School

 

Throughout high school I have challenged myself by taking the most rigorous science courses offered at my school. I have taken enriched physical science, AP Biology, AP Chemistry and Enriched Physics. I also received a 4 on the AP Biology exam and a 3 on the AP Chemistry exam. Finally, I have expanded my learning by participating in the Mentor Connection program offered by Intermediate School District 287. The program has allowed me to advance my learning in a number of ways, including working in a laboratory at the University of Minnesota where I conducted valuable and significant research.

 

 

 

 

 

 

 

 

 

 

Diana Yang

2004 Brooklyn Center High School

 

Sickle cell patients are given morphine to relieve and/or prevent the painful episodes which are common in this disease. It is thought that SC patients might have a higher than normal level of drug metabolizing enzymes, which might then remove morphine from the body at a much faster rate than is seen in non-SC patients. This would cause morphine to be less effective in controlling pain. A possible reason for these high levels of drug metabolizing enzymes is the high bilirubin levels found in SC patients' blood. BR is formed by the breakdown of hemoglobin. This is a normal process that occurs at a faster rate in SC patients, because of the damage done to red blood cells in SC. It has been seen that SC patients have higher than normal levels of BR in their blood. These high BR levels might trigger intracellular pathways that lead to increased expression of these enzymes in SC patients. Our goal is to find the best way to quantify the amount of BR in a plasma sample. Our hypothesis is that high-pressure liquid chromatography provides a better method of quantifying BR than other methods.